Persistent Increases in Cocaine-Seeking Behavior After Acute Exposure to Cold Swim Stress
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چکیده
منابع مشابه
Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment.
To examine neuronal activation associated with incentive motivation for cocaine, cocaine-seeking behavior (operant responding without cocaine reinforcement) and Fos expression were examined in rats exposed to saline and cocaine priming injections and/or a self-administration environment. Rats were first trained to self-administer cocaine or received yoked saline administration ("control"). They...
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Since the discovery of specific mechanisms regulating gene transcription, studies have explored therapeutic avenues in the treatment of disease through such epigenetic targets, including the mechanisms of histone acetylation/deacetylation. Indeed, compounds that inhibit histone deacetylation [i.e., histone deacetylase (HDAC) inhibitors] have been investigated as treatments for a variety of dise...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2010
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2010.03.030